Store:Dry and cool place, keep far away from sunlight
Usage: As an intermediate
Payment terms:T/T via bank transfer,Bitcoin,USDT,Western Union
Package:1kg/aluminium foil bag,25kg/box/barrel
Phenacetin shiny phenacetin China buy Phenacetin powder large stock,Phenacetin crystal fenacetin powder CAS 62-44-2 supplier China,Buy Phenacetin 62 44 2 fenacetin price Phenacetin Powder Cas 62-44-2,Factory price cas 62-44-2 phenacetin powder manufacturer phenacetin price,phenacetin powder,china phenacetin powder,phenacetin large stock,phenacetin stocks,non shiny phenacetin,phenacetin powder price, phenacetin price,phenacetin vendor,phenacetin large stock
Phenacetin (acetophenetidin, N-(4-ethoxyphenyl)acetamide) is a pain-relieving and fever-reducing drug, which was widely used following its introduction in 1887. It was withdrawn from medicinal use as dangerous from the 1970s (e.g., withdrawn in Canada in 1973,and by the U.S. Food and Drug Administration in 1983.
Phenacetin was introduced in 1887 in Elberfeld, Germany by German company Bayer, and was used principally as an analgesic; it was one of the first synthetic fever reducers to go on the market. It is also known historically to be one of the first non-opioid analgesics without anti-inflammatory properties.
Prior to World War One, Britain imported phenacetin from Germany. During the war, a team including Jocelyn Field Thorpe and Martha Annie Whiteley developed a synthesis in Britain.
Known mechanism of action
Phenacetin's analgesic effects are due to its actions on the sensory tracts of the spinal cord. In addition, phenacetin has a depressant action on the heart, where it acts as a negative inotrope. It is an antipyretic, acting on the brain to decrease the temperature set point. It is also used to treat rheumatoid arthritis (subacute type) and intercostal neuralgia.
In vivo, one of two reactions occur. Usually phenacitin's ether is cleaved to leave paracetamol (acetaminophen), which is the clinically relevant analgesic. A minority of the time the acetyl group is removed from the amine, producing carcinogenic P-Phenetidine. This reaction is quite rare, however, as evidenced by the fact that the drug was on the market for almost 100 years before a statistical link was established, when Canada, followed by the United States, withdrew it from the market.
The first synthesis was reported in 1878 by Harmon Northrop Morse.
Phenacetin may be synthesized as an example of the Williamson ether synthesis: ethyl iodide, paracetamol, and anhydrous potassium carbonate are heated in 2-butanone to give the crude product, which is recrystallized from water.
Phenacetin was widely used until the third quarter of the twentieth century, often in the form of an A.P.C., or "aspirin-phenacetin-" compound analgesic, as a remedy for fever and pain. An early formulation (1919) was Vincent's APC in Australia.
In the United States, the Food and Drug Administration ordered the withdrawal of drugs containing phenacetin in November 1983, due to its carcinogenic and kidney-damaging properties. It was also banned in India. As a result, some branded, and previously phenacetin-based, preparations continued to be sold, but with the phenacetin replaced by safer alternatives. A popular brand of phenacetin was Roche's Saridon, which was reformulated in 1983 to contain propyphenazone, paracetamol . Coricidin was also reformulated without phenacetin. Paracetamol is a metabolite of phenacetin with similar analgesic and antipyretic effects, but the new formulation has not been found to have phenacetin's carcinogenicity.
Due to its low cost, phenacetin is used for research into the physical and refractive properties of crystals. It is an ideal compound for this type of research.
In Canada phenacetin is used as a laboratory reagent, and in a few hair dye preparations (as a stabilizer for hydrogen peroxide). While it is considered a prescription drug, no marketed drugs contain phenacetin.
Best quality & best price & guarantee delivery!
And we also have some products in oversea warehouses.As domestic shipping is so fast and guarantee.
Hot selling products:
Phenacetin(Shiny crystalline,non shiny powder),cas62-44-2;
Boric acid flakes/boric acid chunks,cas11113-50-1;
Diethyl 2-(2-phenylacetyl)propanedioate/New bmk,Cas20320-59-6;
New BMK powder,cas 5449-12-7
PMK ethyl glycidate/New Pmk oil/new PMK powder,cas28578-16-7;
Dimethylaminoisopropyl chloride hydrochloride;cas4584-49-0;
If you're looking for a reliable and legit supplier, please feel free to contact us !
Promotion is currently going on of all products,welcome your inquiry.
There are no reviews yet.